Expression of PTTG, bFGF and Endostatin in Colorectal Cancer ...

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Tumor Research

[Abstract]

Objective: PTTG is a new proto-oncogene with high expression in most malignant tumors. Ever since being discovered, this gene was paid close attention to, and becoming investigation hot spot gradually, especially in cell transformation, blood vessel growth, tumor formation, infiltration and metastasis. bFGF is one of the most important angiogenesis promoters ever known. Endostatin is collagen??end fragment. Its molecular mass is 2000. And it is a new factor of antiangiogenesis in clinical test. Oncogenes play the role of tumor angiogenesis in the process of tumor growth. This role is through up-regulating angiogenesis positive factors and / or down-regulating angiogenesis negative factors to achieve. Tumor angiogenes is closely related to its invasiveness, and angiogenesis depends on the balance between endogenous stimulating factors and inhibitors. Immunohistochemical method was used to detect the expressions of PTTG, bFGF and Endostatin and their relationships in colorectal cancer. We approached the effect of PTTG, bFGF and Endostatin in the occurrence of colorectal cancer invasion.Material and Methods: The specimens were taken from Pathology Division of the First Affiliated Hospital of Zhengzhou University from October 2003 to December 2004. They were 57 surgical resected filing wax blocks of colorectal adenocarcinoma, including 28 males and 29 females; The median age was 56 years (31-78 years). By Dukes stage for the A + B 31 cases, C + D 26 cases. 21 cases were well-differentiated, and 36 cases were poorly differentiated. There were 26 cases with lymph nodes metastasis and 31 cases without lymph nodes metastases through conventional lymph nodes check. We used immunohistochemical method to detect the expression of PTTG, bFGF and Endostatin proteins in 57 sections from colorectal cancers, and analyzed the relationship between the protein expression and the clinicopathologic features. Results: 1. The positive rate of PTTG (80.7%) in the period of colorectal adenocarcinoma DukesC+D was higher than the positive rate of PTTG (45.2%)in Dukes A+B.And the difference the difference was statistically significant (P

Title: Expression of PTTG, bFGF and Endostatin in Colorectal Cancer

Category: Tumor Stem Cell

Filename: Expression of PTTG, bFGF and Endostatin in Colorectal Cancer.pdf

Pages: 197

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